Proceedings of the British Toxicology Society Autumn Meeting Keble College, Oxford 12-14 September 1999
Identifieur interne : 002644 ( Main/Exploration ); précédent : 002643; suivant : 002645Proceedings of the British Toxicology Society Autumn Meeting Keble College, Oxford 12-14 September 1999
Auteurs :Source :
- Human and Experimental Toxicology [ 0960-3271 ] ; 1999-12.
English descriptors
- Teeft :
- Abdomen skin, Abstracts localization, Adaptive response, Additional immunostaining, Adduct, Adipose tissue, Aldehyde, Aldehyde metabolising enzymes, Alderley park, Ames, Amine, Anaemia, Andrews, Animal death, Animal model, Animal studies, Aplasia, Aplastic, Aplastic anaemia, Apoptosis, Aryl hydrocarbon receptor, Assay, Barrier creams, Beecham, Benoxaprofen, Best poster presentation, Bile canalicular plasma membrane, Bioassay, Biol chem, Biological sciences, Biomedical, Biomedical sciences, Biomedical sciences department, Blast analysis, Blood changes, Blood values, Body weight, Bugelski, Butadiene monoepoxide, Cacid metabolites, Calc, Cald, Caloric restriction, Canine purkinje fibres, Carcinogen, Carcinogenicity, Cdna, Cdna microarray data, Cdna microarrays, Cell division, Cell proliferation, Cell viability, Charcoal trap, Chem, Chemical risk assessment, Chemical safety, Chemical treatments, Chenspm, Chloroquine, Chronic bone marrow aplasia, Chronic hypoplastic marrow failure, Cinnamyl alcohol, Cisapride, Clinical pharmacology, Clinical pharmacology group, Compensatory tissue repair, Compound, Constitutive androstane mediates, Contact sensitizer, Control group, Current study, Cynomolgus monkey, Cyp2b genes, Cytochrome, Cytotoxicity, Cytotoxicity assay, Dapi staining, Dehp, Different studies, Differential gene expression, Differentially, Diffusion cells, Dnhp, Dos, Dose, Dose response, Dosing regimen, Drug metabolizing enzymes, Dunkin hartley guinea pigs, Electrical stimulation, Electrophoresis investigation, Environmental health criteria, Environmental pollutants, Enzyme, Epithelial cells, Erythromycin, Erythromycin liver toxicity, Ester, Ethylene dibromide, Experimental model, Exposure limits, False positives, Female mice, Final outcome, First step, Flavouring, Flavouring compounds, Fmollmg protein, Food additives, Frythe, Further studies, Gene, Gene expression, Glucuronidation, Good toxicology, Growth factor, Guidance values, Guinea pigs, Haematological results, Hair follicles, Hepatic, Hepatic failure, Hepatocarcinogenesis, Hepatocytes, Hepatotoxicity, Heterocyclic, Heterocyclic amine metabolism, Heterocyclic amines, High doses, Higher liver injury, Hotchkiss, Hour period, Human cells, Human health, Human intestine, Human liver microsome bank, Human placenta slices, Human skin, Human variability, Humans, Hypolipidemic drugs, Imperial college school, Individual cdna fragments, Inhibitor, Interindividual differences, International programme, Interspecies, Interspecies differences, Interval prolongation, Intestine, Joint winner, Kupffer cells, Laboratory animals, Large intestine, Large number, Late stage, Lauric acid, Light microscopy, Liver, Liver growth, Liver injury, Liver regeneration, Liver toxicity, Liver volume, Magnetic resonance imaging, Major component, Male rats, Male sprague dawley rats, Mammalian cells, Mansfield road, Marrow, Marrow cell counts, Marrow depression, Medical school, Mehendale, Melqx, Metabolic, Metabolic fate, Metabolic parameters, Metabolism, Microsome, Mismatch repair, Mitochondrial damage, Molecular biology, Molecular dynamics, Molecular level, Molecular mechanism, Molecular mechanisms, Molecular toxicology, Molecular toxicology group, Mouse, Mouse hepatocytes, Mouse liver, Mouse liver microsomes, Mouse skin, Mrna, Mrna species, Nasal, Nasal cavities, Nasal cavity, Nasal passages, Negligible risk, Nongenotoxic carcinogens, Nuclear receptors, Nucleotide excision repair, Oral gavage, Oxazolone, Oxidative stress, Oxidative stress agents, Parent compound, Partial hepatectomy, Pathway, Pbpk model, Percutaneous, Percutaneous absorption, Percutaneous penetration, Peripheral blood changes, Peroxisome, Peroxisome hepatocarcinogenesis, Peroxisome proliferators, Pharmaceutical, Pharmacol, Pharmacology, Phototoxic hazard, Phthalate, Phthalate esters, Physostigmine, Physostigmine sulphate, Placenta, Placenta slices, Polyamine, Polyamine analogues, Polyamine catabolic enzymes, Ppara, Preapplied pyrazole, Preclinical species, Preliminary experiments, Present study, Presurgery liver volume, Proliferators, Protective effect, Protein adducts, Protein complement, Protein level, Protein synthesis, Purkinje fibres, Rat, Reactive metabolite, Reactive metabolites, Receptor, Receptor fluid, Regeneration, Regulatory view, Renwick, Renwick uncertainty factors, Repair enzymes, Repair process, Repair systems, Reporter gene activity, Resonance imaging, Resveratrol, Reversible reticulocytopenia, Rhesus monkey, Risk assessment, Rodent, Rodent carcinogens, Safety assessment, Safety margins, Salmonella typhimurium, Same conditions, Sebaceous glands, Sensitive animal species, Several drugs, Severe tyrosinemia, Significant decrease, Significant differences, Significant effect, Significant increase, Significant reduction, Silver grains, Skin lesions, Skin models, Small intestine, Smithkline, Smithkline beecham pharmaceuticals, Smooth endoplasmic reticulum, Sodium valproate, Southampton, Species differences, Sprague dawley, Statistical analysis, Statistical significance, Strain differences, Stratum corneum, Subtractive hybridisation, Surface area, Surrey, Survival factors, Target genes, Test compound, Test species, Therapeutic drugs, Time points, Tissue injury, Tissue repair, Topical exposure, Toxic, Toxic chemical vapour, Toxic insult, Toxic responses, Toxicity, Toxicity studies, Toxicol, Toxicological, Toxicology, Toxicology testing, Transcription, Transcription factor, Transcription factors, Transcriptional, Transcriptional regulation, Treatment groups, Tumour, Turton, Typhimurium, Ultimate outcome, Uncertainty factor, Uncertainty factors, Useful tool, Various concentrations, Vivo, Welwyn, White blood cells.
Url:
DOI: 10.1191/096032799678839626
Affiliations:
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<term>Abstracts localization</term>
<term>Adaptive response</term>
<term>Additional immunostaining</term>
<term>Adduct</term>
<term>Adipose tissue</term>
<term>Aldehyde</term>
<term>Aldehyde metabolising enzymes</term>
<term>Alderley park</term>
<term>Ames</term>
<term>Amine</term>
<term>Anaemia</term>
<term>Andrews</term>
<term>Animal death</term>
<term>Animal model</term>
<term>Animal studies</term>
<term>Aplasia</term>
<term>Aplastic</term>
<term>Aplastic anaemia</term>
<term>Apoptosis</term>
<term>Aryl hydrocarbon receptor</term>
<term>Assay</term>
<term>Barrier creams</term>
<term>Beecham</term>
<term>Benoxaprofen</term>
<term>Best poster presentation</term>
<term>Bile canalicular plasma membrane</term>
<term>Bioassay</term>
<term>Biol chem</term>
<term>Biological sciences</term>
<term>Biomedical</term>
<term>Biomedical sciences</term>
<term>Biomedical sciences department</term>
<term>Blast analysis</term>
<term>Blood changes</term>
<term>Blood values</term>
<term>Body weight</term>
<term>Bugelski</term>
<term>Butadiene monoepoxide</term>
<term>Cacid metabolites</term>
<term>Calc</term>
<term>Cald</term>
<term>Caloric restriction</term>
<term>Canine purkinje fibres</term>
<term>Carcinogen</term>
<term>Carcinogenicity</term>
<term>Cdna</term>
<term>Cdna microarray data</term>
<term>Cdna microarrays</term>
<term>Cell division</term>
<term>Cell proliferation</term>
<term>Cell viability</term>
<term>Charcoal trap</term>
<term>Chem</term>
<term>Chemical risk assessment</term>
<term>Chemical safety</term>
<term>Chemical treatments</term>
<term>Chenspm</term>
<term>Chloroquine</term>
<term>Chronic bone marrow aplasia</term>
<term>Chronic hypoplastic marrow failure</term>
<term>Cinnamyl alcohol</term>
<term>Cisapride</term>
<term>Clinical pharmacology</term>
<term>Clinical pharmacology group</term>
<term>Compensatory tissue repair</term>
<term>Compound</term>
<term>Constitutive androstane mediates</term>
<term>Contact sensitizer</term>
<term>Control group</term>
<term>Current study</term>
<term>Cynomolgus monkey</term>
<term>Cyp2b genes</term>
<term>Cytochrome</term>
<term>Cytotoxicity</term>
<term>Cytotoxicity assay</term>
<term>Dapi staining</term>
<term>Dehp</term>
<term>Different studies</term>
<term>Differential gene expression</term>
<term>Differentially</term>
<term>Diffusion cells</term>
<term>Dnhp</term>
<term>Dos</term>
<term>Dose</term>
<term>Dose response</term>
<term>Dosing regimen</term>
<term>Drug metabolizing enzymes</term>
<term>Dunkin hartley guinea pigs</term>
<term>Electrical stimulation</term>
<term>Electrophoresis investigation</term>
<term>Environmental health criteria</term>
<term>Environmental pollutants</term>
<term>Enzyme</term>
<term>Epithelial cells</term>
<term>Erythromycin</term>
<term>Erythromycin liver toxicity</term>
<term>Ester</term>
<term>Ethylene dibromide</term>
<term>Experimental model</term>
<term>Exposure limits</term>
<term>False positives</term>
<term>Female mice</term>
<term>Final outcome</term>
<term>First step</term>
<term>Flavouring</term>
<term>Flavouring compounds</term>
<term>Fmollmg protein</term>
<term>Food additives</term>
<term>Frythe</term>
<term>Further studies</term>
<term>Gene</term>
<term>Gene expression</term>
<term>Glucuronidation</term>
<term>Good toxicology</term>
<term>Growth factor</term>
<term>Guidance values</term>
<term>Guinea pigs</term>
<term>Haematological results</term>
<term>Hair follicles</term>
<term>Hepatic</term>
<term>Hepatic failure</term>
<term>Hepatocarcinogenesis</term>
<term>Hepatocytes</term>
<term>Hepatotoxicity</term>
<term>Heterocyclic</term>
<term>Heterocyclic amine metabolism</term>
<term>Heterocyclic amines</term>
<term>High doses</term>
<term>Higher liver injury</term>
<term>Hotchkiss</term>
<term>Hour period</term>
<term>Human cells</term>
<term>Human health</term>
<term>Human intestine</term>
<term>Human liver microsome bank</term>
<term>Human placenta slices</term>
<term>Human skin</term>
<term>Human variability</term>
<term>Humans</term>
<term>Hypolipidemic drugs</term>
<term>Imperial college school</term>
<term>Individual cdna fragments</term>
<term>Inhibitor</term>
<term>Interindividual differences</term>
<term>International programme</term>
<term>Interspecies</term>
<term>Interspecies differences</term>
<term>Interval prolongation</term>
<term>Intestine</term>
<term>Joint winner</term>
<term>Kupffer cells</term>
<term>Laboratory animals</term>
<term>Large intestine</term>
<term>Large number</term>
<term>Late stage</term>
<term>Lauric acid</term>
<term>Light microscopy</term>
<term>Liver</term>
<term>Liver growth</term>
<term>Liver injury</term>
<term>Liver regeneration</term>
<term>Liver toxicity</term>
<term>Liver volume</term>
<term>Magnetic resonance imaging</term>
<term>Major component</term>
<term>Male rats</term>
<term>Male sprague dawley rats</term>
<term>Mammalian cells</term>
<term>Mansfield road</term>
<term>Marrow</term>
<term>Marrow cell counts</term>
<term>Marrow depression</term>
<term>Medical school</term>
<term>Mehendale</term>
<term>Melqx</term>
<term>Metabolic</term>
<term>Metabolic fate</term>
<term>Metabolic parameters</term>
<term>Metabolism</term>
<term>Microsome</term>
<term>Mismatch repair</term>
<term>Mitochondrial damage</term>
<term>Molecular biology</term>
<term>Molecular dynamics</term>
<term>Molecular level</term>
<term>Molecular mechanism</term>
<term>Molecular mechanisms</term>
<term>Molecular toxicology</term>
<term>Molecular toxicology group</term>
<term>Mouse</term>
<term>Mouse hepatocytes</term>
<term>Mouse liver</term>
<term>Mouse liver microsomes</term>
<term>Mouse skin</term>
<term>Mrna</term>
<term>Mrna species</term>
<term>Nasal</term>
<term>Nasal cavities</term>
<term>Nasal cavity</term>
<term>Nasal passages</term>
<term>Negligible risk</term>
<term>Nongenotoxic carcinogens</term>
<term>Nuclear receptors</term>
<term>Nucleotide excision repair</term>
<term>Oral gavage</term>
<term>Oxazolone</term>
<term>Oxidative stress</term>
<term>Oxidative stress agents</term>
<term>Parent compound</term>
<term>Partial hepatectomy</term>
<term>Pathway</term>
<term>Pbpk model</term>
<term>Percutaneous</term>
<term>Percutaneous absorption</term>
<term>Percutaneous penetration</term>
<term>Peripheral blood changes</term>
<term>Peroxisome</term>
<term>Peroxisome hepatocarcinogenesis</term>
<term>Peroxisome proliferators</term>
<term>Pharmaceutical</term>
<term>Pharmacol</term>
<term>Pharmacology</term>
<term>Phototoxic hazard</term>
<term>Phthalate</term>
<term>Phthalate esters</term>
<term>Physostigmine</term>
<term>Physostigmine sulphate</term>
<term>Placenta</term>
<term>Placenta slices</term>
<term>Polyamine</term>
<term>Polyamine analogues</term>
<term>Polyamine catabolic enzymes</term>
<term>Ppara</term>
<term>Preapplied pyrazole</term>
<term>Preclinical species</term>
<term>Preliminary experiments</term>
<term>Present study</term>
<term>Presurgery liver volume</term>
<term>Proliferators</term>
<term>Protective effect</term>
<term>Protein adducts</term>
<term>Protein complement</term>
<term>Protein level</term>
<term>Protein synthesis</term>
<term>Purkinje fibres</term>
<term>Rat</term>
<term>Reactive metabolite</term>
<term>Reactive metabolites</term>
<term>Receptor</term>
<term>Receptor fluid</term>
<term>Regeneration</term>
<term>Regulatory view</term>
<term>Renwick</term>
<term>Renwick uncertainty factors</term>
<term>Repair enzymes</term>
<term>Repair process</term>
<term>Repair systems</term>
<term>Reporter gene activity</term>
<term>Resonance imaging</term>
<term>Resveratrol</term>
<term>Reversible reticulocytopenia</term>
<term>Rhesus monkey</term>
<term>Risk assessment</term>
<term>Rodent</term>
<term>Rodent carcinogens</term>
<term>Safety assessment</term>
<term>Safety margins</term>
<term>Salmonella typhimurium</term>
<term>Same conditions</term>
<term>Sebaceous glands</term>
<term>Sensitive animal species</term>
<term>Several drugs</term>
<term>Severe tyrosinemia</term>
<term>Significant decrease</term>
<term>Significant differences</term>
<term>Significant effect</term>
<term>Significant increase</term>
<term>Significant reduction</term>
<term>Silver grains</term>
<term>Skin lesions</term>
<term>Skin models</term>
<term>Small intestine</term>
<term>Smithkline</term>
<term>Smithkline beecham pharmaceuticals</term>
<term>Smooth endoplasmic reticulum</term>
<term>Sodium valproate</term>
<term>Southampton</term>
<term>Species differences</term>
<term>Sprague dawley</term>
<term>Statistical analysis</term>
<term>Statistical significance</term>
<term>Strain differences</term>
<term>Stratum corneum</term>
<term>Subtractive hybridisation</term>
<term>Surface area</term>
<term>Surrey</term>
<term>Survival factors</term>
<term>Target genes</term>
<term>Test compound</term>
<term>Test species</term>
<term>Therapeutic drugs</term>
<term>Time points</term>
<term>Tissue injury</term>
<term>Tissue repair</term>
<term>Topical exposure</term>
<term>Toxic</term>
<term>Toxic chemical vapour</term>
<term>Toxic insult</term>
<term>Toxic responses</term>
<term>Toxicity</term>
<term>Toxicity studies</term>
<term>Toxicol</term>
<term>Toxicological</term>
<term>Toxicology</term>
<term>Toxicology testing</term>
<term>Transcription</term>
<term>Transcription factor</term>
<term>Transcription factors</term>
<term>Transcriptional</term>
<term>Transcriptional regulation</term>
<term>Treatment groups</term>
<term>Tumour</term>
<term>Turton</term>
<term>Typhimurium</term>
<term>Ultimate outcome</term>
<term>Uncertainty factor</term>
<term>Uncertainty factors</term>
<term>Useful tool</term>
<term>Various concentrations</term>
<term>Vivo</term>
<term>Welwyn</term>
<term>White blood cells</term>
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